Here, we show that functionalization of the 4-arylidene position of the fluorescent curcumin scaffold with an aryl nitrogen mustard provides a stable Hck inhibitor (Kd = 50 ± 10 nM). The mustard curcumin derivative preferentially interacts with the inactive conformation of Hck, similar to type-II kinase inhibitors that are less promiscuous. Mor

????????, ???????????? - ??????????? ???????? ????? ????? ? ????????????? ???? ? ???????, ????????????, ??????????. ??????? ??? ?????? ? ???? ????? ???????.??????, ????? ??????, ???? ?????, ?? ????????, ???? ??, ??? ?????, ????? ?????My BMC bike has a loose brake lever that touches the grip, and the wheel can spin (makes minimal contact)????? ????,